Note: a SNP (say ’snip’) is a variation in the gene that helps make you unique. Some SNPs come with health and aging risks that can be compensated by specific nutrients. That means that your body may need certain nutrients that you’re not getting in your diet (Milk Thistle, Kale, etc…) and why a DNA customized supplement is essential to your health and aging.

Bone Strength Gene™ – SNP 1: VDR (Vitamin D Receptor)
Detox Gene™ — SNP 2: EPHX (Microsomal Epoxide Hydrolase)
CoQ10 Gene™ — SNP 3: NQ01 (Coenzyme Q10 Reductase)
Superoxide Gene™ Free Radical Defense — SNP 4: SOD2 (Manganese Superoxide Dimutase)
Lung and Breast Tissue Gene™  — SNP 5: GPX1 (Glutathione Peroxidase 1)
Collagen Health Gene™ — SNP 6: MMP-1 (Matrix Metalloproteinase)
Cardiovascular Gene™ — SNP 7: MTRR ( Methionine Sythase Reductase)
Cardiovascular Enzyme Gene™ — SNP 8: MTHFR (Methylene Tetrahydrofolate Reductase)
Inflammation Response Gene™ — – SNP 9: TNF-a (Tumor Necrosis Factor – a)
Cholesterol Oxidation Gene™ — SNP10: PON-1 (Paraxonase 1)
Blood Pressure Gene™ — – SNP 12: ApoB (Apolipoprotein B)

Bone Strength Gene™ — SNP 1: VDR (Vitamin D Receptor) — The strength of our bones is influenced by the VDR gene. In fact, among healthy people, this one gene accounts for 75% of the entire genetic influence on bone density. People with SNPs in the VDR gene tend to have lower bone mineral density than those without these variations. SNPs in this gene may also influence young adult growth, parathyroid hormone production, normal cell division, and blood sugar regulation.

Supportive ingredients include: Calcium (as Calcium Carbonate), Vitamin K1 (as phytonadione), Vitamin D3 (as cholecalciferol).

Detox Gene™ — SNP 2: EPHX (Microsomal Epoxide Hydrolase) — Epoxides are toxic, highly reactive foreign chemicals present in cigarette smoke, car exhaust, charcoal-grilled meat, and smoke from burning wood, pesticides, and alcohol.

The body’s way of dealing with epoxides is through the enzyme microsomal EPHX, which detoxifies these foreign compounds. Due to a SNP on the EPHX gene, people with lowered EPHX activity will have difficulty detoxifying harmful substances and thus be particularly vulnerable to their effects.

Supportive ingredients include: Milk Thistle extract [(Silybum marianum) standardize to 80% silymarin] Oxyphyte® Green Tea extract  [(Camellia sinensis) standardized to 90% polyphenols], Broccoli extract [(Brassica oleracea) standardized to 1.2% sulphoraphane], Burdock Root powder (Arctium pubens), Kale powder (Brassica oleracea), Artichoke extract [(Cynara scolymus) standardized to 4% chlorogenic acid/9% caffeoylquinic acid], Schizandra Berry powder (Schisandra chinensis ), Gotu Kola extract (Centella asiatica).

CoQ10 Gene™ — SNP 3: NQ01 (Coenzyme Q10 Reductase) — Free radicals are considered by many scientists to be the primary cause of aging. The coenzyme Q10 reductase (NQO1) enzyme converts coenzyme Q10 (ubiquinone) to its reduced form, ubiquinol, which scavenges free radicals in the mitochondria and lipid membranes. Some individuals have a SNP in the NQO1 gene that slows the reduction of ubiquinone to ubiquinol, resulting in very low blood levels of this key antioxidant. Consequently, people with this SNP are at high risk of free radical attack. Because NQO1 is also involved in the detoxification of compounds foreign to the body, a SNP in the NQO1 gene may cause aberrant cellular changes.

Supportive ingredients: Ubiquinone or Ubiquinol —  Depends on which form of CoQ10 your body can metabolize. You don’t know unless you run a genetic test.

Superoxide Gene™ Free Radical Defense – SNP 4: SOD2 (Manganese Superoxide Dimutase) — The SOD2 enzyme is also involved in scavenging free radicals. However, SOD2 is focused on one particularly toxic type of free radical: superoxide.xi Since the superoxide radical is produced in abundance in all cells, it is the starting point for the free radical chain of production. SOD2 has the distinction of being the only enzyme in the mitochondria that can neutralize superoxide. Individuals with a SNP in this gene therefore have a weak first line of defense against free radicals.

Supportive ingredients include: Spirulina powder (Arthrospira platensis ), Oxyphyte® Green Tea extract [(Camellia sinensis) standardized to 90% Polyphenols], Oxyphyte® White Tea extract (Camellia sinensis ) standardized to 90% Polyphenols], Bilberry extract [(Vaccinium myrtillus) standardized to 5% anthocyanins], Vitamin B3 (as Niacinamide).

Lung and Breast Tissue Gene™  — SNP 5: GPX1 (Glutathione Peroxidase 1) — The GPX1 antioxidant enzyme specifically scavenges hydrogen peroxide, a reactive oxygen species. GPX1 is a selenoprotein, meaning it incorporates selenium into its protein structure. Therefore, how much GPX1 a person produces is dependent on their selenium level.13 A SNP on the GPX1 gene can reduce a person’s ability to utilize selenium. That means higher-than-normal selenium intake is needed to afford protection to hydrogen peroxide-sensitive tissues, particularly lung and breast tissues.

Supportive ingredients include: Proprietary blend: Citrus Bioflavonoids powder (Citrus limonium, Citrus paradise and Citrus sinensis ), Milk Thistle extract [(Silybum marianum) standardized to 80% silymarin], Astragalus Root powder ( Astragalus membranaceus), Ginkgo Biloba extract [(Ginkgo biloba) standardized to 24% Flavoglycosides/6% Terpene Lactones], Oxyphyte® Grape Skin extract [(Vitis vinifera) standardized to 10% resveratrol], Alpha Lipoic Acid, Organic Blueberry extract [(Vaccinium angustifolium) standardized to 2% polyphenols], Organic Black Currant extract [( Ribes nigrum) standardized to 2% polyphenols], Tumeric extract [(Curcuma longa) standardized to 95% curcumin], Garlic Powder (Allium sativum), Selenium (as Selenium Amino Acid Chelate). Citrus Bioflavonoids powder (Citrus limonium, Citrus paradise and Citrussinensis ), Milk Thistle extract [(Silybum marianum) standardized to 80% silymarin], Astragalus Rootpowder ( Astragalus membranaceus), Ginkgo Biloba extract [(Ginkgo biloba) standardized to24% Flavoglycosides/6% Terpene Lactones], Oxyphyte® Grape Skin extract [(Vitis vinifera) standardizedto 10% resveratrol], Alpha Lipoic Acid, Organic Blueberry extract [(Vaccinium angustifolium) standardized to 2% polyphenols], Organic Black Currant extract [( Ribes nigrum) standardized to 2% polyphenols],Tumeric extract [(Curcuma longa) standardized to 95% curcumin], Garlic Powder (Allium sativum),Selenium (as Selenium Amino Acid Chelate).

Collagen Health Gene™ — SNP 6: MMP-1 (Matrix Metalloproteinase) — Collagen is the main component of cartilage, ligaments, tendons, and bone. It is constantly synthesized and broken down in an on-going cycle. MMP1, also known as collagenase, is an enzyme that degrades collagen. People with a SNP in the MMP1 gene produce collagenase at an increased rate, which means their bodies may break down collagen faster than they can rebuild it. These individuals will likely benefit from added support for collagen-rich structures such as the bones and joints.

Supportive ingredients include: Tomato powder [(Solanum lycopersicum) standardized to 0.8% lycopene], Oxyphyte® White Tea extract [(Camellia sinensis) standardized to 90% polyphenols], Oxyphyte® Grape Seed extract [(Vitis vinifera) standardized to 95% polyphenols].

Cardiovascular Gene ™ — SNP 7: MTRR ( Methionine Sythase Reductase) — Homocysteine is a metabolite of the amino acid methionine. Research has shown it is important to control homocysteine levels in order to preserve cardiovascular health. One of the body’s methods for keeping homocysteine levels in check is the MTRR enzyme, which transforms homocysteine back to either methionine or cysteine. When an individual has a SNP in the MTRR gene, their ability to clear homocysteine from the blood may be hindered. However, only certain population groups appear to be negatively affected by this SNP.

Supportive ingredients include: Trimethylglycine, Zinc (as Zinc Amino Acid Chelate), Dong Quai extract [(Angelica sinensis) standardized to 1.0% Ligustilide], Vitamin B3 (as Niacinamide), Vitamin B2, (as Riboflavin), Vitamin B12 (as Cyanocobalamin), Vitamin B6 (as Pyridoxine hydrochloride), Folate (as folic acid). Trimethylglycine, Zinc(as Zinc Amino Acid Chelate), Dong Quai extract [(Angelica sinensis) standardized to 1.0% Ligustilide], Vitamin B3 (as Niacinamide), Vitamin B2, (as Riboflavin), Vitamin B12 (as Cyanocobalamin), Vitamin B6(as Pyridoxine hydrochloride), Folate (as folic acid).

Cardiovascular Enzyme Gene™  — SNP 8: MTHFR (Methylene Tetrahydrofolate Reductase) — Like the MTRR enzyme, the MTHFR enzyme is responsible for reducing blood levels of homocysteine. People with a SNP in the MTHFR gene manufacture defective enzymes that can’t clear homocysteine from the blood efficiently. Research has shown there is a direct association between a SNP in the MRHFR gene and elevated levels of homocysteine, particularly in those with low levels of folate.

Supportive ingredients include: Trimethylglycine, Choline Bitartrate, L-methlyfolate.

Inflammation Response Gene™ — SNP 9: TNF-a (Tumor Necrosis Factor – a) — Inflammation is a response of the immune system to a perceived attack. While it is a helpful response in the short-term, if inflammation continues on-going, it can negatively affect the cells, tissues, and ultimately, the organs. TNF- is a cytokine (a chemical messenger of the immune system) that plays a role in inflammatory processes. Individuals with a SNP on the TNF- gene may have an over-reactive inflammation mechanism,which can negatively affect the joints, brain, lungs, and heart.

Supportive ingredients include: Milk Thistle extract [(Silybum marianum) standardized to 80% Silymarin], Oxyphyte® Green Tea extract [(Camellia sinensis) standardized to 90% Polyphenols], Pomegranate extract [( Punica granatum) standardized to 40% Ellagic Acid], Oxyphyte® Grape Seed extract [(Vitis vinifera) standardized to 95% polyphenols].

 

Cholesterol Oxidation Gene™  — SNP10: PON-1 (Paraxonase 1) — While it used to be thought that high cholesterol posed a health issue in and of itself, it is now believed that cholesterol only becomes a problem once the cholesterol carrier, low-density lipoprotein (LDL), becomes oxidized (attacked by free radicals). The PON1 enzyme attaches itself to high-density lipoprotein (HDL), which protects both HDL and LDL from oxidation. Due to common SNPs in the PON1 gene, blood levels of PON1 can vary by a factor of 10 to 40-fold among different individuals. Those with low levels of PON1 have higher levels of oxidized LDL, which can lead to diminished cardiovascular health.

Supportive ingredients include: Organic Reshi Mushroom extract (Granoderma lucidum), Organic Shitake Mushroom extract (Lentinus edodes), Maitake Mushroom extract [(Grifola frondosa) standardized to 20% polysaccharides], Vitamin E (as dl-alpha tocopherol acetate).

 

Blood Pressure Gene™ — SNP 11: CYP11B2 (Aldosterone Synthase) — Maintaining blood pressure within the normal range is essential to a healthy heart. The CYP11B2 gene encodes an enzyme called aldosterone synthase, which plays a role in regulating blood pressure. A SNP on the CYP11B2 gene can decrease the ability of blood vessels to relax and constrict in response to changing demands for blood flow. (For example, extra blood flow is needed during exercise.) That inability of the vessels to respond properly can set the stage for cardiovascular issues down the road.

Supportive ingredients include: Potassium (as Tripotassium citrate monohydrate), Organic Hawthorn Berry extract [(Crataegus laevigata) standardized to 1.5% polyphenols/0.5% flavonoids], Magnesium (as Magnesium Citrate), Acerola Cherry Extract [( Malpighia glabra) standardized to 17% Vitamin C], Garlic powder (Allium sativum). Potassium (as Tripotassium citrate monohydrate), Organic Hawthorn Berry extract [(Crataegus laevigata) standardized to 1.5% polyphenols/0.5% flavonoids], Magnesium (as Magnesium Citrate), Acerola Cherry Extract[( Malpighia glabra) standardized to 17% Vitamin C], Garlic powder (Allium sativum).

Cholesterol Gene™ — SNP 12: ApoB (Apolipoprotein B) — Cholesterol is carried through the bloodstream on various lipoproteins: low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL).

Apolipoproteins make up the protein part of lipoproteins. One of the more researched apolipoproteins is apolipoprotein B (ApoB); it constitutes the protein component of LDL, the “bad” kind of cholesterol carrier. In fact, without ApoB, LDL cannot form. Because people with SNPs on the ApoB gene have higher ApoB levels, they experience moderate increases in total cholesterol, LDL cholesterol, and triglycerides, as well as impaired glucose tolerancex and increased blood lipid response after meals.

Supportive ingredients include: Oxyphyte® Green Tea extract [(Camellia sinensis) standardized to 90% polyphenols], Pomegranate extract [( Punica granatum) standardized to 40% ellagic acid], Artichoke extract [(Cynara scolymus) standardized to 4% chlorogenic acid/9% caffeolyquinic acid], Oxyphyte® Grape Skin extract [(Vitis vinifera) standardized to 10% resveratrol].

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How does it work?

The key area in skin repair is the dermis, a layer of skin sandwiched between the outer epidermis and the deep hypodermis. The dermis contains blood vessels that nourish the skin, and proteins called elastin and collagen that keep it taut. As we age, our bodies struggle to replenish stores of collagen and elastin, and some people are genetically primed to break these down faster than others. The patented, non-invasive simple swab allows you to peek into your predispositions to discover what your genes have to say about your skin aging future.

Then, depending on the level of need identified in your genetic assessment, our laboratory blends a combination of active ingredients to create your personal DNA customized formulation. Through a liposomal delivery sys­tem similar to the nicotine patch and birth control patch, the ingredients go beneath the first layer of dead skin cells to the dermis where all the benefits of antioxidants and vitamins can work to help replenish and restore collagen and elastin.

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 DNA profiling revolutionized the legal world, and now it’s doing the same for skin care. Now the same technology can be used to identify a whole new set of perpetrators. The main suspects? Collagen breakdown, sun damage, sen­sitivity, environmental pollution free radical toxicity caused by oxidative stress.

So how do you know how susceptible you are to these aging culprits?

Take a minute to swab inside your cheek. Place your DNA sample inside our bar-coded envelope, and send to our lab. We assess six skin health genes to tell you what skin aging problems you’re likely to face as you age.

The information is then used to customize a skin repair serum using a combination of active ingredients selected to compensate for particular deficiencies in areas of skin aging, wrinkling, collagen breakdown, irritation and the skin’s ability to defend against environmental stresses.

For more information on how to have your genes assessed, CLICK HERE

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LifeMap ME (made exclusively) is the first and only DNA-Customized Skin Repair Serum. Not only is GeneLink LEADING the field of Dermagenetics™; you might almost say GeneLink OWNS the field, having trademarked the name and patented the technology behind it.

GeneLink’s Dermagenetics™ profile is designed to evaluate an individual’s susceptibility to skin aging by examining genetic based risks for oxidative damage, environmental stresses, irritation and photo-aging. The resulting Dermagenetics™ test information is used to formulate skin care products that are designed to ameliorate the individual’s disadvantaged “skin health” state, if any. GeneLink’s Dermagenetics™ test does not examine SNPs directly related to skin diseases. We do not diagnose nor treat skin diseases or disorders.

We know that beauty is more than skin deep, but skin is extremely important in the perception–and the reality–of aging. Healthy skin, our largest organ, has many valuable functions, and DNA has a lot to do with skin health. Your LifeMap ME (made exclusively) Skin Repair Serum is custom made for your particular needs, based on your genetic profile. You can be confident that the ingredients inside are the ones that will make the biggest difference relevant to your predispositions for aging.

The new skin product will be officially launched in Mid September, along with training and marketing materials (both online and in our magazine). Those of you who received the Skin Serum at the August “One Of A Kind” Celebration have a head start in using the product, falling in love with it, seeing your own results, and creating your own stories around this revolutionary new skin repair serum.

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Consumers are trying to prevent and minimize the effects of aging, with particular focus on using nutrients to combat skin wrinkling.

The recent demand in anti-aging products stem from 5 key elements in the marketplace.  These include:

1. An aging population concerned with long term Health and Energy Levels
2. The ever growing trend to take a proactive approach to health care
3. Technological advancements in formulations and quality of products
4. Busy consumers demanding immediate results
5. Baby Boomers making up over 25% of the population

More people are recognizing that our bodies produce less nutrients as we grow older, specifically in the area of hormones such as growth hormone.

The genetic age brought on by the completion of the Human Genome Project provides some real answers to how all of us can know exactly what type of predispositions we are born with.

The results of Genetic Assessment can now provide the EXACT nutrient intake that will not only support our genetic predispositions, but will also help support nutrient deficiencies.

Companies like GeneWize Life Sciences, that are focused on the finest ingredients to produce the best possible products will begin to set the trend for the future of individualized nutrition and nutritional products.

Savvy consumers are starting to demand not only the highest quality ingredients, but will also be asking for measurable assessments to indicate the exact nutrients needed on a daily basis.

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